Cosequin DS Plus MSM & Omega-3s contains FCHG49 Glucosamine Hydrochloride, TRH122 Sodium Chondroitin Sulfate, and MSM (Methylsulfonylmethane). This combination of ingredients helps to protect your dog's joints and support healthy cartilage matrix production. Each soft chew also contains omega-3 fatty acids to help support skin & coat health